Test Bank For McCance & Huether’s Pathophysiology The Biologic Basis for Disease in Adults and Children 9th Edition

Chapter 1: Cellular Biology MULTIPLE CHOICE

1. Which statement best describes the cellular function of metabolic absorption?

1. Cells can produce proteins. c. Cells can take in and use nutrients.
2. Cells can secrete digestive enzymes. d. Cells can synthesize fats.

ANS: C
In metabolic absorption, all cells take in and use nutrients and other substances from their surroundings. The remaining options are not inclusive in their descriptions of cellular metabolic absorption.

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2. Most of a cell’s genetic information, including RNA and DNA, is contained in the: a. Mitochondria c. Nucleolus
b. Ribosome d. Lysosome

ANS: C
The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of the cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its activity. The other options do not contain most of a cell’s genetic information.

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3. Which component of the cell prodNuUceRsSIhNyGdTroBg.CeOnMperoxide (H2O2) by using oxygen to remove hydrogen atoms from specific substrates in an oxidative reaction?
a. Lysosomes c. Ribosomes
b. Peroxisomes d. Oxyhydrosomes

ANS: B
Peroxisomes are so named because they usually contain enzymes that use oxygen to remove hydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes. Ribosomes are RNA-protein complexes (nucleoproteins) that are synthesized in the nucleolus and secreted into the cytoplasm through pores in the nuclear envelope called nuclear pore complexes. Lysosomes are saclike structures that originate from the Golgi complex and contain more than 40 digestive enzymes called hydrolases, which catalyze bonds in proteins, lipids, nucleic acids, and carbohydrates. Oxyhydrosomes are involved in enzyme production.

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4. Which cell component is capable of cellular autodigestion when it is released during cell injury?

1. Ribosome
2. Golgi complex

ANS: D

c. Smooth endoplasmic reticulum d. Lysosomes

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The lysosomal membrane acts as a protective shield between the powerful digestive enzymes within the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix. Disruption of the membrane by various treatments or cellular injury leads to a release of the lysosomal enzymes, which can then react with their specific substrates, causing cellular self-digestion. The other options do not correctly describe this process.

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5. What is the sequence of steps in the development of a digestive enzyme by the pancreas cells from the initial transcription to the release from the cell?

1. The enzyme is transcribed from DNA by RNA in the nucleus, proceeds to the

   ribosome for synthesis, and is transported in a secretory vesicle to the cell

   membrane.

2. The enzyme is transcribed from RNA by DNA in the nucleus, proceeds to the

   lysosome for synthesis, and is transported in an encapsulated membrane to the cell

   membrane.

3. The enzyme is transcribed by the mitochondria in the nucleus, proceeds to the

   ribosome for synthesis, and is transported in a cytoskeleton to the cell membrane.

4. The enzyme is transcribed from DNA by RNA in the nucleus, proceeds to the

   Golgi complex for synthesis, and is transported in a cytosol to the cell membrane.

ANS: A
The enzyme is transcribed from DNA by RNA in the nucleus, proceeds to the ribosome for synthesis, and is transported in a secretory vesicle to the cell membrane. The other options do not correctly describe this process.

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6. During which phase of the cell cycle is DNA synthesized? a. G1 c. G2
b. S d.M

ANS: B
The four designated phases of the cell cycle are: (1) the G1 phase (G = gap), which is the period between the M phase (M = mitosis) and the start of DNA synthesis; (2) the S phase (S = synthesis), during which DNA is synthesized in the cell nucleus; (3) the G2 phase, during which RNA and protein synthesis occurs, the period between the completion of DNA synthesis and the next phase (M); and (4) the M phase, which includes nuclear and cytoplasmic division.

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7. What organic compound facilitates transportation across cell membranes by acting as receptors, transport channels for electrolytes, and enzymes to drive active pumps?

a. Lipids
b. Proteases

ANS: C

c. Proteins
d. Carbohydrates

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Proteins act as (1) recognition and binding units (receptors) for substances moving in and out of the cell; (2) pores or transport channels for various electrically charged particles called ions or electrolytes and specific carriers for amino acids and monosaccharides; and (3) specific enzymes that drive active pumps that promote the concentration of certain ions, particularly potassium (K+), within the cell while keeping concentrations of other ions, for example, sodium (Na+), below the concentrations found in the extracellular environment. The other options do not correctly describe this process.

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8. Understanding the various steps of proteolytic cascades, such as caspase-mediated apoptosis and complement cascades, may be useful in designing drug therapy for which human diseases?

1. Cardiac and vascular disorders
2. Autoimmune and malignant disorders
3. Gastrointestinal and renal disorders
4. Endocrine and gastrointestinal disorders

ANS: B
Understanding the various steps involved in this process is crucial for designing drug interventions. Dysregulation of proteases features prominently in many human diseases, including cancer, autoimmunity, and neurodegenerative disorders. The other options do not correctly describe this process.

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9. Which structure prevents water-soluble molecules from entering cells across the plasma membrane?

1. Carbohydrate chains c. Membrane channel proteins
2. Glycoprotein channels d. Lipid bilayer

ANS: D
The bilayer’s structure accounts for one of the essential functions of the plasma membrane. It is impermeable to most water-soluble molecules (molecules that dissolve in water) because the water-soluble molecules are insoluble in the oily core region. The bilayer serves as a barrier to the diffusion of water and hydrophilic substances while allowing lipid-soluble molecules, such as oxygen (O2) and carbon dioxide (CO2), to diffuse through it readily. The other options do not correctly describe this process.

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